Oregon State University

High Altitude Biochemistry, Physiology, and Adaptation of the Quechua Indians in South America

TitleHigh Altitude Biochemistry, Physiology, and Adaptation of the Quechua Indians in South America
Publication TypeThesis
Year of Publication2000
AuthorsShaver, Kyle John
Academic DepartmentBiochemistry and Biophysics
Thesis AdvisorWidrick, Jeff
DegreeHonors Baccalaureate of Arts in International Studies in Biochemistry and Biophysics
Number of Pages72
Date Published06/2000
UniversityOregon State University
CityCorvallis
Thesis TypeUndergraduate
Keywordsadaptation, High altitude, South America
Abstract

The study of high altitude effects on humans has progressed rapidly in the past hundred years. Researchers have made discoveries about molecular processes, the oxygen transport system, and genotypic adaptation. More information has led to more questions, and the ongoing debates are an indication that there is still much to be determined about biochemical and physiological adaptation.
At 3500m, almost all ascending lowlanders experience unequivocal signs and symptoms of high altitude. The resulting physiological and biochemical responses affect every system in the human body. The respiratory system, the circulatory system, and the heart are the most directly influenced and have been studied extensively.
Relatively high population density, extensive infrastructure, and duration of exposure make the Quechua Indians of South America an ideal source of information about genotypic adaptation and the advanced stages of acclimatization. An analysis of workload capacity and genetic contributions also show distinct differences between lowlanders and the Quechua people.
High altitude studies have the potential to uncover many aspects of metabolism, adaptive physiology, and genetic evolution that cannot be observed in any other conditions. There are also numerous medical applications for treatment of high altitude illnesses and other oxygen limiting conditions.

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