Protein Structure

Structure/Function

• Primary - sequence of amino acids
• Secondary - interactions between amino acids close in primary sequence
  • Phi/Psi angles - HERE
  • Alpha-Helix - HERE / HERE / HERE
  • Beta Strands/Sheets - HERE / HERE
  • Turns - HERE
  • Motifs - Barrel HERE
  • Collagen Triple Helix - HERE / Sequence HERE
    • Hydoxylysine and Hydroxyproline HERE
• Fibrous and Globular Proteins
• Tertiary Structure HERE
  • Forces - HERE
  • Techniques for determination - X-Ray Crystallography and NMR
  • Example
    • Myoglobin - Heme Oxygen Binding - HERE/ HERE
  • Denaturation - HERE
  • Refolding - HERE
• Quaternary Structure
  • Hemoglobin
    • Structure - HERE
    • Oxygen Binding - HERE
      • Bohr Effect - HERE / HERE
      • BPG - HERE / HERE / HERE
    • Fetal Hemoglobin - HERE

Protein Folding

• Prediction - HERE
• Hydrophobicity
• Aggregation /chaperones - HERE / HERE
• Prions -HERE