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alpha-Tropomyosin gene organization (rat) and seven alternative splicing pathways

Exons (red = constitutive, green = smooth muscle-specific, yellow = striated muscle-specific, and white = variable) are indicated with their encoded amino acids (numbered). Experimentally documented splicing pathways (solid lines) and others (dotted lines) inferred from nuclease protection mapping are shown. The smooth and striated exons encoding amino acids 39-80 are mutually exclusive, and there are alternate 3'-terminal exons as well. UT signifies untranslated regions.

Adapted from R. E. Breithart et al., Annu. Rev. Biochem. (1987) 56:467-495. © 1987 Annual Reviews.