Plasma Protein Behavior at Synthetic Surfaces

Presented by: Darcy Myers
Mentors: Michelle K. Bothwell & Joseph McGuire
Bioengineering, Oregon State University

Abstract
The behavior of proteins at the surfaces of synthetic materials is extremely important in areas relevant to the biocompatibility of blood-contacting implants and similar devices where blood clots can form or bacterial adhesion can occur, causing latent, deep infections. A usable, quantitative understanding of the nature of protein adsorption competition in plasma is needed before the problems in biocompatibility can be successfully addressed. In this research, the electro-optical techniques of ellipsometry and infrared spectroscopy are being used to measure the adsorption behavior of selected plasma proteins at synthetic surfaces. The proteins albumin, fibrinogen, and Immunoglobulin G have been selected because they are plasma proteins known to compete for sights at synthetic surfaces and play important roles in the clotting process. The goal of this research is to eventually allow for accurate prediction of plasma protein behavior in practical circumstances.