College of Veterinary Medicine

Assistant Professor
Virology

214 Dryden Hall
541-737-6532 (reception)
541-737-2730 (fax)
cvm.biomed@oregonstate.edu

Education and Professional Training

• DVM
  
• PhD

Professional Organizations

• American Society for Virology
• American Association for the Advancement of Science
• Phi Zeta-honorary Society of Veterinary Medicine
• Gamma Sigma Delta-honorary Society of Agriculture, Illinois

Professional Awards

• 1994: International Student Fellowship at University of Illinois
• 1994: University Research Grand Award
• 1995 & 1997: The American Society for Virology Travel Award
• 1997: University Illinois Graduate College Conference Travel Grant
• 2001: NIH F32 EY13907-01 Individual Research Service Award
• 2005: Animal Health and Disease/USDA
• 2005: Alpaca Research Foundation 2007: CMV Internal Research Grant

Professional and Research Interests

• Pathogenesis of herpes virus infected animal disease
• Host and virus interaction in central nervous system
• Mechanism of herpes virus latency-reactivation cycles
• Anti-viral drug development

Selected Publications

Jin L, Cebra CK, Baker RJ, Mattson DE, Cohen SA, Rohrmann GF. Analysis of the Genome Sequence of an Alpaca Coronavirus. Virology. 2007;365(1):198-203.

Jin L, Perng GC, Carpenter D, Mott KR, Osorio N, Naito J, Brick DJ, Jones C, Wechsler SL. 2006. Reactivation Phenotype in Rabbits of a Herpes Simplex Virus Type 1 (HSV-1) Mutant Containing an Unrelated Anti-Apoptosis Gene in Place of LAT. J Neurovirol. 2007;13(1):78-84.

Chan D, Cohen J, Naito J, Mott KR, Osorio N, Jin L, Fraser NW, Jones C, Wechsler SL, Perng GC. A mutant deleted for most of the herpes simplex virus type 1 (HSV-1) UOL gene does not affect the spontaneous reactivation phenotype in rabbits. J Neurovirol. 2006;12(1):5-16.

Naito J, Mott KR, Osorio N, Jin L, Perng GC. Herpes simplex virus type 1 immediate-early protein ICP0 diffuses out of infected rabbit corneas. J Gen Virol. 2005; 86(Pt 11): 2979-88.

Jin L, Perng GC, Mott KR, Osorio N, Naito J, Brick DJ, Carpenter D, Jones C, Wechsler SL. 2005. A herpes simplex virus type 1 mutant expressing a baculovirus inhibitor of apoptosis gene in place of Latency Associated Transcript has a wild-type reactivation phenotype in the mouse. J Virol. 2005;79(19):12286-95.

Peng W, Jin L, Henderson G, Perng GC, Brick DJ, Nesburn AB, Wechsler SL, Jones C. Mapping herpes simplex virus type 1 latency-associated transcript sequences that protect from apoptosis mediated by a plasmid expressing caspase-8. J Neurovirol. 2004;10(4):260-5.

Jin L, Perng GC, Mott KR, Osorio N, Naito J, Brick D, Carpenter D, Jones C, Wechsler SL. 2004. Replacement of LAT by the well characterized anti-apoptosis gene, cpIAP, results in a high wild type HSV-1 reactivation phenotype. Manuscript

Jin L, Perng GC, Brick DJ, Naito J, Nesburn AB, Jones C, Wechsler SL. Methods for detecting the HSV-1 LAT anti-apoptosis activity in infected tissue cultures cells. J. Virological Methods. 2004;118(1):9-13.

Jin L, Peng W, Perng GC, Nesburn AB, Jones C, Wechsler SL. Identification of herpes simplex virus type 1 latency-associated transcript sequences that both inhibit apoptosis and enhance the spontaneous reactivation phenotype. J. Virol. 2003;77(11):6556-61.

Henderson G, Peng W, Jin L, Perng GC, Nesburn AB, Wechsler SL, Jones C. Regulation of caspase 8- and caspase 9-induced apoptosis by the herpes simplex virus type 1 latency-associated transcript. J Neurovirol. 2002;8(Suppl 2):103-11.

Perng GC, Maguen B, Jin L, Mott KR, L Benmonhamed, Yukht A, Osorio N, Nesburn AB, Inman M, Henderson G, Jones C, Wechsler SL. A novel herpes simplex virus 1 transcript (AL-RNA) antisense to the 5' end of latency-associated transcript produces a protein in infected rabbits. J Virol. 2002;76(16):8003-8010.

Perng GC, Maguen B, Jin L, Mott KR, Osorio N, Slanina SM, Yukht A, Ghiasi H, Nesburn AB, Inman M, Henderson G, Jones C, Wechsler SL. A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levels. J Virol. 2002;76(3):1224-1235.

Perng GC, Esmaili D, Slanina SM, Yukht A, Ghiasi H, Osorio N, Mott KR, Maguen B, Jin L, Nesburn AB, Wechsler SL. Three herpes simplex virus type 1 latency-associated transcript mutants with distinct and asymmetric effects on virulence in mice compared with rabbits. J Virol. 2001;75(19):9018-28.

Jin L, Schnitzlein WM, Scherba G. Identification of the pseudorabies virus promoter required for latency-associated transcript gene expression in the natural host. J Virol. 2000;74(14)6333-6338.

Jin L, Scherba G. Expression of pseudorabies virus latency-associated transcript gene during productive infection of cultured cells. J Virol. 1999;73(12):9781-9788.

Jin L. 1999. Pseudorabies Virus latency associated transcript gene: Expression and Regulation, and role in the establishment of latency in swine. Jin, UMI, Ann Arbor.

Scherba G, Wiemers JF, Siegel AM, Jin L, Austin CC, Bowman L, Redeford B, Johnston NA, Weigel RM. Application of a quantitative algorithm to restriction endonuclease analysis of Aujeszky's disease (pseudorabies) virus from a geographically localized outbreak. J Vet Diag Invest. 1999;11(5):423-431.

Weigel RM, Scherba G, Wiemers J, Siegel AM, Austin CC, Jin L, Bowman L, Johnston NA. 1997. Application of quantitative methods and molecular biological techniques to investigation of the spread of Aujeszky's disease virus. Epidemiologie et Sante Animale 31-31: 12.17.1-12.17.2.

Jin L, Schnitzlein WM, Scherba G. 1995. Establishment of latency in the natural host animal by Aujeszky's disease (pseudorabies) virus lacking the putative LAT gene promoter. In: Advances in Swine in Biomedical Research, Vol. 1, M.E. Tumbleson and L.B. Shock (eds), Plenum Publishing, NY. pp395-408.