Christiane V. Löhr, Dr. med. vet., PhD, DACVP
Assistant Professor
Christiane.Loehr@oregonstate.edu
American Association of Veterinary Laboratory Diagnosticians (AAVLD)
American College of Veterinary Pathologists (ACVP)
European College of Veterinary Pathologists (ESVP)
German Veterinary Medical Association (DVG)
International Academy of Pathology (IAP)
2002 Charles Louis Davis Foundation Student Scholarship Award, New Orleans, LA
2001 Graduate Student Competition Award, American Association of Veterinary Laboratory Diagnosticians, Hershey, PA
2000 Postdoctoral Fellowship, German Academy of Sciences (Deutsche Akademie der Naturwissenschaftler Leopoldina)
1997 Karl Pfizer Award for Doctoral Thesis in Veterinary Medicine, Justus-Liebig University, Giessen, Germany
1995 Doctoral Fellowship, State of Hesse, Germany (Promotionsstipendium nach dem Gesetz zur Förderung von Nachwuchswissenschaftlern, HGFöN)
2003 Diplomate of the American College of Veterinary Pathologist
2002 PhD in Veterinary Sciences, Washington State University, Pullman
1998 Certification as Veterinary Pathologist, Germany
1996 Dr. med. vet. (Pathology), Justus-Liebig Universität, Giessen, Germany
1992 Veterinary degree, Justus-Liebig Universität, Giessen, Germany
As veterinary anatomic pathologist my interests and activities cover a wide range:
To understand the pathogenesis of neoplastic disease has been my motivation to choose a career in pathology and research. I am pursuing this interest through multiple avenues.
Equine sarcoids are the most common skin tumors in horses and are associated with bovine papillomavirus type 1 and 2 infections. Equine sarcoids are locally invasive growing tumors that can result in impairment of function. They are a treatment challenge, which is reflected by their high recurrence rate. A preliminary clinical trial conducted by Dr. Scott Gustafson utilized photodynamic therapy and showed promising results. We are examining the effect of photodynamic therapy on cultured normal fibroblasts and primary cell lines derived from equine sarcoids to understand the mechanism of cell death and to optimize treatment strategies. Interestingly, a similar entity was recently discovered in cats-feline sarcoids. These tumors have close gross and histologic resemblance to the equine neoplasm, yet their clinical behavior is much more innocuous. They are associated with a papillomavirus, and the partial characterization was part of a recent research project and has been published.
Ongoing collaborative projects examine phytochemicals as possible chemopreventatives in the development of ultraviolet (UV)-induced skin cancer and immunosuppression and in the transplacental carcinogenesis in response to dibenzo[a,1]pyrene (DBP), a potent polycyclic aromatic hydrocarbon (PAH).
Tissue and Cell Analysis Facilities and Service core of the Environmental Health Sciences Center supports the research efforts of principal investigators from a variety of institutions at OSU and is co-directed by Dr. Nancy Kerkvliet and me. Support and collaborative activities of the pathology unit are provided in the form of gross and histopathology, electron microscopy and the development and quality assurance of immunohistochemical and in situ hybridization assays. Senior research assistant, Kay Fischer, is instrumental to these efforts.
C.B. Cope, C. Camp, C.V. Löhr. Fatal yew (Taxus sp.) poisoning in Willamette Valley, Oregon, horses. Vet Human Toxicol (2004) 46:279-281.
C.V. Löhr, K.A. Brayton, A.F. Barbet, G.H. Palmer. Characterization of the Anaplasma marginale msp2 locus and its synteny with the omp1/p30 loci of Ehrlichia chaffeensis and E. canis. Gene (2004) 325:115-121.
J.P. Teifke, B.A. Kidney, C.V. Löhr, J.A. Yager. Detection of papillomavirus DNA in mesenchymal tumor cells and not the hyperplastic epithelium of feline sarcoids. Veterinary Dermatology (2003) 14:47-56.
C.V. Löhr, K.A. Brayton, V. Shkap, T. Molad, A.F. Barbet, G.H. Palmer. Expression of major surface protein 2 oper-associated genes in Anaplasma marginale during mammalian and arthropod infection. Infection and Immunity (2002) 70:6005-6012.
C.V. Löhr, F.R. Rurangirwa, T.F. McElwain, D. Stiller, G.H. Palmer. Expression of Anaplasma marginale major surface protein 2 salivary gland variants during tick transmission. Infection and Immunity (2002) 70:114-120.
J.P. Teifke, C.V. Löhr, R.E. Marshang, N. Osterrieder, H. Posthaus. Detection of chelonid herpesvirus DNA by nonradioactive in situ hybridization in tissues from tortoises suffering from stomatitis-rhinitis complex in Europe and North America. Veterinary Pathology (2000) 37:377-385.
H. Nieper, J.P. Teifke, A. Jungmann, C.V. Löhr, H. Müller. Infected and apoptotic cells in the IBDV-infected bursa of Fabricius, studied by double-labeling techniques. Avian Pathology (1999) 28:279-285.
J.P. Teifke, C.V. Löhr, H. Shirasawa. Detection of canine oral papillomavirus (COPV)-DNA in canine oral squamous cell carcinomas and p53 overexpressing skin papillomas of the dog using the polymerase chain reaction and nonradioactive in situ hybridization. Veterinary Microbiology (1998) 60:119-130.
C.V. Löhr, J.P. Teifke, A. Trunk, H. Kümper: Thrombarteritis of the patent ductus arteriosus and A. pulmonalis in a 4-year-old cow. Veterinary Record (1997) 141:151-152.
C.V. Löhr, J.P. Teifke, K. Failing, E. Weiss: Characterization of the proliferation state in canine mammary tumors by the standardized AgNOR-method with postfixation and immunohistological detection of Ki-67 and PCNA. Veterinary Pathology (1997) 34:212-221.
C.V. Löhr, J.P. Teifke, E. Weiss: Assessment of AgNORs in canine mammary tumors by image analysis using the standardized AgNOR-method. Electronic Journal of Pathology (1997) 3.1:971-11.txt.
J.P. Teifke and C.V. Löhr. Immunohistochemical detection of p53 overexpression in paraffin-wax embedded squamous cell carcinomas of cattle, horses, cats and dogs. Journal of Comparative Pathology (1996) 114:205-210.