Linda Lou Blythe, DVM, PhD
Professor
American Veterinary Medical Association
Oregon Veterinary Medical Association
International Sled Dog Association
Honor Societies of Phi Kappa Phi and Phi Zeta
1974 DVM University of California at Davis
1975 Internship in Large Animal Surgery UC at Davis
1979 PhD UC at Davis
Regent's Scholar, University of California, Davis, California 1970-74
University of California Veterinary School Medalist, University of California, Davis, California 1974
National Institutes of Health Fellowship, University of California, Davis, California 1976
Oregon Veterinary Medical Association, Distinguished Service Award (President's Award) 1983
Norden Distinguished Teaching Award, College of Veterinary Medicine, Oregon State University 1986
Oregon State University Burlington Northern Foundation Faculty Achievement Award 1989
World Greyhound Racing Federation Diploma of Excellence 1990
Smith Kline Beecham Award for Creativity in Teaching 1991
Norden Distinguished Teaching Award, College of Veterinary Medicine, Oregon State University 1992
Pfizer Award for Research Excellence 1996
James Yarbourgh Lecturer for International Canine Sports Medicine Symposium 1998
Dr. Blythe's research interests are in three distinct areas. Trained as a veterinary neurologist, she has studied equine neurological diseases including equine degenerative myeloencephalopathy and the role of vitamin E in its pathogenesis, equine temporohyoid-osteoarthropathy, and equine protozoal myelopathy. Mapping of the peripheral nervous system by neurophysiological techniques has resulted in sensory maps that allow a clinician to localize acute peripheral nerve injuries by testing the horse for perception of touch and pain in various cutaneous areas of the limbs. A second area of interest is in care of the racing and retired Greyhound as well as drug testing in this breed of racing animals. The third area of interest is in toxic plants in collaboration with Dr. Morrie Craig's laboratory with specific interest in endophytic fungus and pyrrolizidine alkaloid toxicosis.
Blythe LL, Kitchell RL. Electrophysiological studies of the thoracic limb of the horse. American Journal of Veterinary Research 1982;43(9):1511-1524.
Hunt LD, Blythe LL, Holtan DW. Ryegrass staggers in ponies fed processed ryegrass straw. Journal of the American Veterinary Medical Association 1983;182(3):285-286.
Blythe LL, Kitchell RL, Holliday TA, Johnson RD. Sensory nerve conduction velocities in the equine forelimb. American Journal of Veterinary Research 1983;44(8):1419-1426.
Blythe LL, Skinner S, Roelke M, Schmitz JA. Chronic encephalomyelitis caused by canine distemper virus in a Bengal tiger. Journal of the American Veterinary Medical Association 1983;183(11): 1159-1162.
Blythe LL, Watrous BJ, Schmitz JA, Kaneps AJ. Vestibular syndrome associated with temporohyoid joint fusion and temporal bone fracture in three horses. Journal of the American Veterinary Medical Association 1984;185(7):775-781.
Blythe LL, Mattson DE, Lassen ED, Craig AM. Antibodies against equine herpesvirus I in the cerebrospinal fluid in the horse. Canadian Veterinary Journal 1985;26(7):218-220.
Wagner PC, Grant BD, Watrous BJ, Appell LH, Blythe LL. A study of the heritability of cervical vertebral malformation in horses. Proceedings of the 31st Annual Convention of the American Association of Equine Practitioners, Toronto, Canada. 1985. pp 43-50.
Blythe LL, Hansen DE. Factors affecting prerace dehydration and performance of racing Greyhounds. Journal of the American Veterinary Medical Association 1986;189:1572-1574.
Lassen ED, Craig AM, Blythe LL. The effects of racing on hematologic and serum biochemical values in Greyhounds. Journal of the American Veterinary Medical Association 1986;188(11):1299-1303.
Blythe LL, Craig AM, Christensen JM, Appell LH, Slizeski ML. Pharmacokinetic disposition of dimethyl sulfoxide administered intravenously to horses. American Journal of Veterinary Research 1986; 47(3):1739-1743.
Craig AM, Blythe LL, Appell LH, Slizeski ML. Evaluation of the potential for interference by dimethyl sulfoxide (DMSO) in drug detection in racing animals. Journal of Veterinary Pharmacology and Therapeutics 1987;10:298-304.
Blythe LL, Engel HN, Rowe KE. Comparison of sensory nerve conduction velocities in horses versus ponies. American Journal of Veterinary Research 1988;49(12):2138-2142.
Craig AM, Walker LL, Blythe LL, Lassen ED. The scourge of procaine in the Greyhound racing industry and current research solutions. Proceedings of the 4th Annual International Racing Greyhound Symposium, Orlando, Florida. January, 1989. pp 42-44.
Craig AM, Blythe LL, Lassen ED, Rowe KE, Barrington R, Slizeski M. Variations of serum vitamin E, cholesterol and total serum lipids in horses over a 72-hour period. American Journal of Veterinary Research 1989;50(9):1527-1531.
Blythe LL, Craig AM, Lassen ED. Vitamin E in the horse and its relationship to equine degenerative myeloencephalopathy. Proceedings of the 7th American College of Veterinary Internal Medicine Forum, San Diego, California. May, 1989. pp 1007-1010.
Craig AM, Blythe LL. Testing for procaine residues. Proceedings of the 7th International Symposium on the Racing Greyhounds. Orlando, Florida. January, 1991.
Craig AM, Blythe LL, Rowe KE, Lassen ED, Walker LL. Evaluation of the oral vitamin E absorption test in horses. American Journal Veterinary Research 1991;52(6):912-916.
Blythe LL, Hultgren BD, Craig AM, Appell LH, Lassen ED, Slizeski ML, Duffield D. Clinical, viral, and genetic evaluation of equine degenerative myeloencephalopathy in a family of Appaloosas. Journal of the American Veterinary Medical Association 1991;198(6):1005-1013.
Blythe LL, Craig AM, Lassen ED, Rowe KE, Appell, LH, Walker LL. Serially determined plasma -tocopherol concentrations and results of the oral vitamin E absorption test in clinically normal horses and in horses with degenerative myeloencephalopathy. American Journal of Veterinary Research 1991;52(6):908-911.
Blythe LL, Craig AM. Equine degenerative myeloencephalopathy. Part I. Clinical Signs and Pathogenesis. Compendium for Continuing Education - Practicing Veterinarian 1992;14(9):1215-1221.
Craig AM, Latham CJ, Blythe LL, Schmotzer WB, O'Conner OA. Metabolism of toxic pyrrolizidine alkaloids from tansy ragwort, Senecio jacobaea, in ovine ruminal fluid under anaerobic conditions. Applied and Environmental Microbiology 1992;58(9):2730-2736.
Wachenheim DE, Blythe LL, Craig AM. Effects of antibacterial agents on in vitro ovine ruminal biodegradation of the hepatotoxic pyrrolizidine alkaloid, jacobine. Applied and Environmental Microbiology 1992;58(8):2559-2564.
Blythe LL, Craig AM. Equine degenerative myeloencephalopathy. Part II. Diagnosis and Treatment. Compendium for Continuing Education - Practicing Veterinarian 1992;14(12):1633-1637.
Roy DN, Spencer PS, Craig AM, Blythe LL, Allen CN, Lefor M, Seelig M, Kayton R. Yellow star thistle and nigropallidal encephalomalacia: search for culpable neurotoxin(s). The Toxicologist 1992;12:1251, 323.
Wachenheim DE, Blythe LL, Craig AM. Characterization of rumen bacterial pyrrolizidine alkaloid biotransformation in ruminants of various species. Veterinary and Human Toxicology 1992;34(6): 513-517.
Appell LH, Blythe LL, Lassen ED, Craig AM. Adverse effects of rapid intravenous DMSO administration in horses.Journal of Equine Veterinary Science 1992;12(4):215-218.
Craig AM, Blythe LL, Rowe KE, Lassen ED, Barrington BS, Walker KC. Variability in -tocopherol values associated with sample procurement, storage, and freezing of equine serum and plasma samples. American Journal Veterinary Research 1992;53(12):2228-2234.
Blythe LL, Walker LL, Lassen ED, Rowe KE, Engel HN. Nerve conduction velocity in racing Greyhounds. Proceedings of the 11th American College of Veterinary Internal Medicine Forum, Washington, DC. May, 1993.
Roy DN, Craig AM, Blythe LL, Kayton RE, Spencer PS. Equine nigropallidal encephalomalacia and Centaurea solstitialis (yellow star thistle): Partial isolation and identification of neurotoxins. Neurodegeneration 1993;2:51-61.
Blythe LL, Watrous BJ, Shires GMH, Kaneps AJ, vonMatthiessen PW, Riebold TW. Prophylactic partial stylohyoidostectomy for horses with osteoarthropathy of the temporohyoid joint.Journal of Equine Veterinary Science 1994;14(1):32-37.
Blythe LL, Craig AM, Harris LE. Detection and clearance times of legitimate medication in racing Greyhounds. Proceedings, 10th International Conference of Racing Analysts and Veterinarians, Stockholm, Sweden, July 1994.
Craig AM, Blythe LL, Harris LE, Cota P. Routine thin layer chromatography (TLC) of urine from Greyhounds given illicit drugs and legitimate medications. Proceedings, 10th International Conference of Racing Analysts and Veterinarians, Stockholm, Sweden, July 1994.
Pearson EG, Andreasen CB, Blythe LL, Craig AM. Atypical pneumonia associated with ryegrass staggers in calves. Journal of the American Veterinary Medical Association 1996; 209 (6): 1137-1142.
Blythe LL, Granstrom D, Hansen DE, Walker LL, Bartlett J, Stamper S. Serological prevalance of antibodies to Sarcocystis neurona in horses residing in Oregon. Journal of the American Veterinary Medical Association 1997; 210 (4): 525-527.
Blythe LL. Equine degenerative myeloencephalopathy--Genetics and treatment. Proceedings, International Equine Neurology Conference, Cornell University, Ithaca, NY, July, 1997, 22-27.
Blythe LL. Temporohyoid Osteoarthropathy--Otitis media/interna. Proceedings, International Equine Neurology Conference, Cornell University, Ithaca, NY, July, 1997, 30-33.
Craig AM and Blythe LL. Pathophysiology and detection of injuries in canine athletes. Proceedings North American Veterinary Conference at the International Canine Sports Medicine Symposium. Orlando, Florida, Jan, 1998, 675-677.
Blythe LL and Craig AM. Overview of current prophylactic and treatment methods for canine athletes." Proceedings North American Veterinary Conference at the International Canine Sports Medicine Symposium. Orlando, Florida, Jan, 1998, 677-679.
Blythe LL and Craig AM. Antioxidants and canine athletes. Proceedings North American Veterinary Conference at the International Canine Sports Medicine Symposium. Orlando, Florida, Jan, 1998, 680-681. Reprinted in the Greyhound Review, August, 1998, 21-23.
Craig AM and Blythe LL. Drugs and drugs detection in athletic dogs. Proceedings, North American Veterinary Conference at the International Canine Sports Medicine Symposium. Orlando, Florida, Jan, 1998, 682-684.
Tor-Agbidye, Palmer VS, Sabri MI, Craig, AM, Blythe LL, and Spencer PS. Dietary deficiency of cystine and methionine in rats alters thiol homeostasis required for cyanide detoxification.Journal of Toxicology and Environmental Health, Pt A; 1998, 55(8): 583-595.
Tor-Agbidye J, Palmer VS, Spencer PS, Craig AM, Blythe LL & Sabri MI. Sodium cyanate alters glutathione homeostasis in rodent deficient malnourished populations in Africa. Brain Research, (February 27, 1999) 820 (1-2):12-19.
Tor-Agbidye J, Plamer VS, Lasarev MR, Craig AM, Blythe LL, Sabri MI, & Spencer PS - "Bioactivation of cyanide to cyanate in sulfur amino acid deficiency: relevance to neurological disease in humans subsisting on cassava." Toxicological Sciences, (August 1999) 50:228-235.
Rosonke BJ, Brown SR, Tornquist SJ, Snyder SP, Garner MM, Blythe LL. Encephalomyelitis associated with a Sarcocystis neurona-like organism in a sea otter. Journal of the American Veterinary Medical Association 1999; 215 (12): 1839-1842.
Blythe LL, McCubbin JA, and TW Riebold. Editors of the Proceedings of the First International Symposium on Rehabilitation and Physical Therapy. Corvallis, Oregon, August 1999, pp 1-212.
Craig AM, Blythe LL. Characterization of the toxic alkaloids in tall fescue (festuca arundinaces) and perennial ryegrass (lolium perenne) and correlation with clinical disease. Proceedings of the 9th Congress of the International Society of Animal Clinical Biochemistry. Toulouse, France. July 2000. Revue de Medecine Veterinaire, July 2000;686.
Blythe LL, Craig AM. Alpha tocopherol values in athletic dogs. Proceedings of the 9th Congress of the International Society of Animal Clinical Biochemistry. Toulouse, France. July 2000. Revue de Medecine Veterinaire, July 2000;670.
Blythe LL, Engel HN, Pearson EG, Craig AM. Safety Studies and Use of Western Juniper for Animal Bedding. 6th International Symposium on Poisonous Plants, Glasgow, Scotland, August 6-11, 2001. Abstract and poster
Tor-Agbidye J, Blythe LL, Craig AM. Correlation of endophyte toxins (ergovaline and lolitrem B) with clinical disease: Fescue Foot and Perennial Ryegrass Staggers. Veterinary and Human Toxicology. 2001;43(3):140-146.
Blythe LL. Sled Dog Injuries. Proceedings of the Second International Symposium on Rehabilitation and Physical Therapy in Veterinary Medicine. Aug 10-14, 2002. Invited Speaker
Blythe LL. Equine neurological conditions. Proceedings of the Second International Symposium on Rehabilitation and Physical Therapy in Veterinary Medicine. Aug 10-14, 2002. Invited Speaker
Blythe LL, Lehner AF, Tobin T, Pielstick L, Craig AM. Ergopeptide chromatograms associated with endophyte-infected tall fescue toxicosis. Proceedings of the 11th Congress of the International Society of Animal Clinical Biochemistry (ISACB). Valdivia, Chile. April 2004; p. 101.
BOOKS:
Blythe LL. Neurological Examination of the Horse. In: Veterinary Clinics of North America: Equine Practice, pp 255-281. S Reed (ed). 1987.
Blythe LL, Craig AM. International Greyhound Research Database. Hall Directory, Inc. Topeka, Kansas. 1st edition, 1990; 2nd edition, 1991; 3rd edition, 1992; 4th edition, 1994; 5th edition, 1996; Annual Update Web based Database at agcouncil.com. 1997 to present.
Blythe LL, Craig AM. Equine Degenerative Myeloencephalopathy. In: Current Therapy in Equine Medicine III, pp 559-561. Robinson NE (ed). W.B. Saunders Co., Philadelphia, Pennsylvania. 1992.
Blythe LL, Craig AM. Clinical and preclinical diagnostic aids to hepatic plant toxicosis in horses, sheep and cattle. In: Plant-Associated Toxins: Agricultural, Phytochemical and Ecological Aspects, pp 313-318. SM Colegate and PR Dorling (eds). CAB International, Wallingford, England. 1994.
Blythe LL, Gannon JR, Craig AM. Care of the Racing Greyhound: A Guide for Trainers, Breeders, and Veterinarians. American Greyhound Council. Graphic Arts Center, Portland, Oregon. 1994.
Blythe LL, Craig AM, Harris LE. Detection and clearance times of legitimate medication in racing Greyhounds. Proceedings 10th International Conference of Racing Analysts and Veterinarians, pp 290-293, R & W Publications (Newmarket) Limited, Stockholm, Sweden. 1995.
Blythe LL. Otitis media/interna and temporohyoid osteoarthropathy. Veterinary Clinics of North America. WB Saunders, Philadelphia, April, 1997. 13 (1) pp. 21-42.
Blythe LL and Craig AM. Degenerative Myelopathy. In Current Therapy in Equine Medicine 4. Ed. NE Robinson. WB Saunders Co. Philadelphia. 1997. pp. 319-320.
Blythe LL. Peripheral Neuropathy. InCurrent Therapy in Equine Medicine 4. Ed. NE Robinson. WB Saunders Co. Philadephia. 1997. pp. 314-318.
Blythe LL and Watrous BJ. Temporohyiod Osteoarthropathy (Middle Ear Disease). In Current Therapy in Equine Medicine 4. Ed. NE Robinson. WB Saunders Co. Philadephia. 1997. pp. 323-325.
Blythe LL. Determination and localization of spinal cord and peripheral nerve lesions. In Current Techniques in Small Animal Surgery, 4th ED. Ed by MJ Bojrab. Williams and Wilkins Co. Philadelphia, 1997, pp. 798-803.
Blythe LL, Andreason CB, Pearson EG, Craig AM. Atypical pneumonia associated with ryegrass staggers in calves. In Toxic Plants and Other Natural Toxicants. T Garland, AC Barr (Eds). CAB International, New York, NY, 1998, pp 531-536.
Blythe LL. Neurological dysfunction in sporting and working dogs. In: Canine Sports Medicine and Surgery. Ed. Ms Bloomberg, Dee J, and Taylor, R. WB Saunders Co. Philadelphia, 1998, pp 48-56.
Frank AA, Blythe LL, Spencer PS. Aspects of Veterinary Neurotoxicology. In: Experimental Clinical Neurotoxicolgy, 2nd Edition. PS Spencer and H Schaumburg (eds). Oxford University Press, New York, 2000: pp 83-105
Blythe LL, Engel HN. Neuroanatomy and Neurological Examination. In: Veterinary Clinics of North America, Equine Practice, Back Problems. Ed. KK Haussler, WB Saunders, Philadelphia, April, 1999, pp 71-86.
Blythe LL, McCubbin JA, and TW Riebold. Editors of the Proceedings of the First International Symposium on Rehabilitation and Physical Therapy. Corvallis, Oregon, August 1999, pp 1-212.