Illustration by Long Lam

Barely a century has passed since Louis Pasteur developed a vaccination for rabies. Since then, scientists have discovered treatments for some of the worst human scourges: smallpox, tuberculosis, polio and influenza. Much of their success can be traced to experiments on animals under circumstances that would shock us today.

Pasteur learned about rabies by infecting guinea pigs, rabbits and dogs with the invariably fatal disease. In the 20th century, the search for a polio vaccine took the lives of millions of monkeys (rhesus macaques). AIDS researchers still rely on monkeys to understand how the immune system responds to HIV and why some (sooty mangabeys) harbor the virus but never develop the disease.

In her book, Experimenting with Humans and Animals, From Galen to Animal Rights (Johns Hopkins University Press, 2003), Anita Guerrini tells the story of the scientists whose achievements transformed medical care and of the controversies that erupted around the use of animals for science. “It’s about how this theme traces through the Western tradition and enters into the history of medicine,” says Guerrini, a historian and Horning Professor in the Humanities at Oregon State University.

Everyday Cruelty

Advances in medical knowledge and the debate over human and animal rights go back to ancient Greece and Rome. They surface again in 17th century England, a time “when dancing bears, bears fighting with dogs, cockfighting and all manner of cat torture were commonplace, and everyday cruelty to animals was the rule rather than the exception,” writes Guerrini.Scientists such as William Harvey, Robert Boyle and Robert Hooke experimented on insects, rabbits, birds, fish, deer and dogs (Harvey even dissected the dead bodies of his wife’s dearly loved parrot and his own father) in the name of science. Harvey’s success in describing the circulatory system “brought animal experimentation into the forefront as a scientific method,” Guerrini adds.

Guerrini traces the philosophical roots of arguments for and against vivisection (the cutting of live animals) and of the trade-off between suffering and knowledge. For example, Rene Descartes argued that animals lack souls and can’t suffer in the way that humans can, but few accepted this argument.

England passed the first national law to regulate animal research in 1876. It took the United States 90 years to follow suit with the Animal Welfare Act. “Up to then, we had always trusted scientists to do the right thing,” Guerrini says. In 1985, universities and other organizations were required to establish institutional animal care and use committees (IACUC) to enforce higher standards of inspection and care. Those years also saw the rise of citizen activism through groups such as the Animal Liberation Front and People for the Ethical Treatment of Animals.

Before coming to Oregon State in 2008, Guerrini served on the IACUC at the University of California, Santa Barbara. She is now a member of OSU’s IACUC.

In her own research, Guerrini is completing a book on anatomical research in pre-French Revolution Paris and looking at urban animals in pre-modern Paris and London.

Illustration by Scott Laumann

When Spanish expeditions explored what is now the Santa Barbara, California, region in the 16th and 17th centuries, they found thriving native communities. Explorers’ diaries reported that the Chumash people were farming, harvesting shellfish and crafting canoes from local trees. Since then, archaeologists have documented more than 8,000 years of human habitation there.

For OSU historian Anita Guerrini such evidence of human influence on the land must be considered in modern restoration efforts, whether for salmon, marine mammals or birds such as the snowy plover.

“The goal of restoration is to create a self-sustaining environment,” says Guerrini, who came to OSU last summer as one of two holders of the Thomas Hart and Mary Jones Horning Chair in the Humanities. “You have to figure human use into it. You can’t just say, ‘OK, if we take the people out, this is what’s going to happen.’ But you can’t just take people out. You have to deal with that.”

In her previous post at the University of California, Santa Barbara (UCSB), Guerrini taught in the history and environmental studies departments. She was a member and chair of UCSB’s Institutional Animal Care and Use Committee. Her focus on restoration arose unexpectedly from what started as a narrow historical study of an oceanfront reserve on the UCSB campus. Bordered by a heavily urbanized area, the land is the target of plans that include development restrictions and ecological restoration.

In the course of her study, Guerrini discovered that both she and UCSB marine ecologist Jenifer Dugan had an interest in expanding the kinds of evidence that could be used to set restoration goals. They collaborated on a three-year project funded by the National Endowment for the Humanities to explore the role of history in restoration.

Their report (upcoming in Restoria, edited by Marcus Hall) cites examples of dramatic coastal change and concludes that restoration should go beyond a specific set of conditions. “In this coastal context, it can only mean restoring the ecological processes, not a particular point in time,” they write. “Larger answers to the challenge of developing restoration goals for the . . . coasts of the world will require a synthesis of physical and ecological dynamics and processes, anthropology, history, sea level change, natural and cultural resources, and human population growth and needs.”

National parks, especially those that preserve history, face a similar challenge, Guerrini says. “Gettysburg is an example of this. It’s an historic but also an ecological site. How do you preserve history while making it ecologically sustainable? Do you keep the trees as they were in 1863?” she asks.

Guerrini has published on the history of European science, medicine and animal experimentation. She is currently working on a book about the groundbreaking contributions of animal anatomical studies to the study of natural history in Paris during the reign of Louis XIV. She has been a visiting fellow in Paris, Canberra and Edinburgh as well as at the OSU Center for the Humanities.