Project 1 – PAHs in Humans at Environmental Levels: Pharmacokinetics, Metabolism and Susceptible Individuals
David Williams, Project Leader
PAHs are environmental contaminants prevelant at Superfund Sites and represent 3 top 10 most hazardous substances (ATSDR Priority List of Hazardous Substances). A major obstacle for regulator agenencies is lack of human data. We will characterize uptake/elimination of BaP in humans at environmental levels and identify susecptible individuals.This provides critical data for health risk from environmetal exposure to PAHs.
Project 2 – Cross-Species and Life Stage Comparisons of PAH Dosimetry
Richard Corley, Project Leader
This project will expand our collaborations to develop the next generation of PBPK models capable of predicting target tissue doses of metabolites important for PAH toxicity at potentially susceptible stages of life.
Project 3 – Systems Approach to Define Toxicity of Complex PAH Mixtures
Robert Tanguay, Project Leader
This project will define the mechanisms of PAH toxicity via the zebrafish assay