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Synthesis of Bis-Heterocyclic Alkaloids

 

Reference ID:	OSU Docket 00-09
Inventors:	David Horne and Kenichi Yakushijin
Description:	This invention is a short synthesis of nortopsentins B and D and topsentin A from oxotryptamine which was prepared from acyl cyanide; readily available starting materials. The bisindole alkaloids, nortopsentin and topsentin represent a class of deep-sea sponge metabolites. In the past, the poor supply of these compounds has hindered their development by the pharmaceutical industry. This synthesis method avoids the use of sea sponges as the source of the compounds.
Applications:	Nortopsentin and topsentin have received much attention due to their potent biological activities as antitumor, antiviral, and anti-inflammatory agents.
License Terms:	Available for exclusive licensing.
Patent Status:	U.S. patent application has been filed

 

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