Pharmaceutical Formulation for the Prophylaxis, Pretreatment, and Treatment of a Poisoning Caused by Exposure to Organophosphorus Cholinesterase

Reference ID: OSU-06-31

Inventors: Dr. John Mata, Dr. Carole Jubert, Dr. Stephen Dunfield, Dr. Stephen Gustafson

Description:  This present invention includes a pharmaceutical formulation for the prophylaxis, preliminary treatment or treatment of a poisoning caused by organophosphorus cholinesterase inhibitors, vesicating agents, polycyclic aromatic hydrocarbon or aflatoxin B1.   The invention is characterized by active substance comprised of a metaloporphyrin molecule with an associated metal moiety ( Cu, Zn, Mg) of suitable purity and chemical composition to provide a bioavailable oral dosage form to attain predictable concentrations in target tissues and bodily fluids sufficient to counteract the effects of toxic substances through chemical complexation or catalysis of toxin degradation.

The invention provides pharmaceutical formulations releasing suitable active substances in a controlled manner for the prophylactic treatment of poisoning by said poisons.

Applications: Biotechnology                               

                       Pharmaceutical drug development

License Terms: Available for exclusive or non-exclusive terms

Patent Status: US patent pending

 

For more information, contact:

Mitra Kiani, Licensing Associate
Technology Transfer Office
Oregon State University
308 Kerr Administration Building
Corvallis, Oregon 97331-2140, USA
E-mail: Mitra.Kiani@oregonstate.edu

Telephone: (541) 737-3030
Facsimile: (541) 737-3093