IACUC Policy on the Use of Non-Pharmaceutical Grade Compounds
Principal Investigators are expected to use pharmaceutical-grade compounds (medications, vehicles, carriers) for all live vertebrate animal work. The use of non-pharmaceutical-grade compounds is only permitted following review and approval by the IACUC.
It may be acceptable to use non-pharmaceutical-grade materials in non-survival procedures, as long as their use does not affect the well-being of the animal or compromise the validity of the study. Purification or sterilization of non-pharmaceutical compounds should occur, where appropriate. A complete description must be included in the “Animal Care and Use Proposal” (ACUP) or in an amendment form and approved by the IACUC prior to use in live animals.
Reasons for such exceptions can include scientific necessity and non-availability of an acceptable veterinary or human pharmaceutical-grade product. Cost savings are not an adequate justification for using non-pharmaceutical-grade compounds in animals.
The United States Department of Agriculture (USDA) Animal Care Policy #3 (http://www.aphis.usda.gov/ac/policy3.html)
Office of Laboratory Animal Welfare (OLAW) FAQ
IACUC approved 2-9-11