|
Table 1.
The prion diseases |
|
| Disease |
Host |
Mechanism of pathogenesis |
|
| Kuru |
Fore people |
Infection through
ritualistic cannibalism |
| iCJD |
Humans |
Infection from prion-contaminated
HGH, dura mater grafts, etc. |
| vCJD |
Humans |
Infection from
bovine prions? |
| fCJD |
Humans |
Germ-line mutations in PrP gene |
| GSS |
Humans |
Germ-line mutations
in PrP gene |
| FFI |
Humans |
Germ-line mutation in PrP gene
(D178N, M129) |
| sCJD |
Humans |
Somatic mutation
or spontaneous conversion of PrPC into PrPSc? |
| FSI |
Humans |
Somatic mutation or spontaneous
conversion of PrPC into PrPSc? |
| Scrapie |
Sheep |
Infection in
genetically susceptible sheep |
| BSE |
Cattle |
Infection with prion-contaminated
MBM |
| TME |
Mink |
Infection with
prions from sheep or cattle |
| CWD |
Mule deer, elk |
Unknown |
| FSE |
Cats |
Infection with
prion-contaminated bovine tissues or MBM |
| Exotic ungulate encephalopathy |
Greater kudu, nyala, oryx |
Infection with prion-contaminated
MBM |
|
|
iCJD, iatrogenic
CJD; vCJD, variant CJD; fCJD, familial CJD; sCJD,
sporadic CJD; GSS, Gerstmann-Sträussler-Sheinker
disease; FFI, fatal
familial insomnia; FSI,
fatal sporadic insomnia; BSE, bovine spongiform encephalopathy;
TME, transmissible mink encephalopathy; CWD, chronic
wasting disease; FSE, feline spongiform encephalopathy;
HGH, human growth hormone; MBM, meat and bone meal.
Note: iatrogenic
= caused by medical treatment.
|