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Figure E2

(Left panel) Illustration of base-pairing and stacking interactions in yeast tRNAPhe. Base-pairs stabilizing secondary and tertiary structure are drawn as bent or fused slabs or by connecting two slabs with rods. Note stacking of bases 34 to 38 in the anticodon loop, consisting of the anticodon Gm34-A35-A36. Letters a to g indicate where base pairs and triplets displayed in the right panel are located.

(Right panel) Unusual base-base interactions found in yeast tRNAPhe. All other base-pairs are of the Watson-Crick type. Flags at glycosyl links indicate backbone orientations. They are parallel in c, e, f (m2G10, G45), g (A9, A23), h (C13, m7G46) and antiparallel otherwise. a is a "wobble" base pair. b is a reversed Hoogsteen base pair. e is a reversed Watson-Crick base pair with both chains oriented parallel.