Biosynthesis of Membrane Lipids Outline
Notes HERE

Pathway integration HERE

Glycerophosphospholipids/Fat

• Phosphatidate synthesis HERE
• Phosphatidate to Fat HERE
• Phosphatidate to CDP-diacylglycerol HERE / CDP-diacylglycercol structure HERE
• CDP-diacylglycerol to phosphatidylinositol HERE

Alternative pathway in mammals to synthesis of phosphatidyl compounds

• Ethanolamine + ATP <=> Phosphorylethanolamine + ADP (see next line for figure)
• Phosphorylethanolamine + CTP <=> CDP-ethanolamine + PPi HERE
• Synthesis of phosphatidylcholine HERE

Sphingolipid Biosynthesis

• Sphingosine structure HERE
• Palmitoyl-CoA + Serine + H⁺ <=> Dehyrdrosphingosine + CO₂ + CoA HERE
• Ceramide synthesis HERE
• Sphingomyelin, cerebroside, ganglioside synthesis HERE

• Ganglioside structure (Figure 26.4)
• Lipids in lysosome (Figure 26.5)
• Enzyme reaction absent in Tay-Sachs disease HERE

Cholesterol Biosynthesis

• Cholesterol labeling HERE
  
• HMG-CoA fates HERE
• Isoprene HERE
• Isopentenyl pyrophosphate synthesis HERE
• Dimethylallyl pyrophosphate synthesis HERE
• Condensation to form geranyl/farnesyl pyrophosphate HERE
• Geranyl pyrophosphate and farnesyl pyrophosphate and squalene synthesis HERE
• Squalene conversion to lanosterol HERE
• Lanosterol to cholesterol conversion HERE
• SREBP pathway HERE

Body Transport of Lipids

• Plasma lipoproteins HERE
• VLDL synthesis/secretion HERE
• LDL schematic HERE
• Lipoprotein particle fates HERE
• Endocytosis of LDL HERE
• LDL domains HERE
• Atherosclerotic plaque HERE
• Familial hypercholesterolemia HERE
• Lovastatin HERE

Cholesterol Metabolites

• Bile salt synthesis HERE
• Steroid hormone synthesis scheme HERE
• Cholesterol numbering HERE
• Hydroxylation of steroids by cytochrome p450 HERE
• Steroid hormone syntheses HERE and HERE
• Vitamin D synthesis HERE