Replication of Nucleic Acids

Central Dogma - HERE

DNA Replication

• Semi-Conservative Replication - HERE
• Bi-Directional Replication - HERE
• Polymerization by DNA Polymerase - HERE
  • Modified nucleosides as drugs - HERE
• Replication Fork - HERE (Leading vs. Lagging, Okazaki Fragments)
• DNA Polymerases of E. coli
  • Properties - TABLE
  • Pol III Holoenzyme Subunits - TABLE
    • Beta Clamp - HERE and HERE
• Other Proteins for DNA Replication
  • Topoisomerases (Gyrase) - HERE
  • At Replication Fork - HERE
• Proofreading - HERE
• DNA Repair
  • Role of exonucleases - HERE
  • Thymine Dimers (nucleotide excision) - HERE / HERE
  • Oxidation Damage (base excision) - HERE
  • Mismatch Repair - HERE
• Cytosine vs. Thymine vs. Uracil - HERE / HERE
• Eukaryotes
  • Cell Cycle - HERE
  • DNA Replication Initiation Model - HERE
  • DNA Polymerases - TABLE
  • PCNA
  • Telomerase and Cancer - HERE / HERE / HERE
  • Replication differences - Prokaryotic vs. Eukaryotic - TABLE