Fatty Acid Metabolism

Adipocyte image (HERE)

Basic Principles

• Fatty acid degradation/synthesis (HERE)
• Fat emulsifier - glycocholate (HERE)
• Fat breakdown in digestive system - pancreatic lipases (HERE)
• Fats exiting digestive system (HERE)
• Fat breakdown in adipocytes (HERE)
• Activation/regulation of triacylglycerol lipase in adipocytes (HERE)
• Conversion of glycerol (HERE)
• Lipolysis (HERE)

Fatty Acid Oxidation

• Attachment to CoA (HERE)
• Attachment to carnitine for transport (HERE)
• Oxidation here (HERE and HERE)
• Fatty acid oxidation reaction summary (HERE)
• Monounsaturarted fatty acid oxidation (HERE)
• Linoleoyl CoA oxidation (HERE)
• Propionyl-CoA metabolism (HERE)
• Vitamin B₁₂ (HERE) Mechanism (HERE, HERE, and HERE)
• Peroxisome (HERE) / Peroxisomal fatty acid oxidation (HERE)

Ketone Bodies

• Formation (HERE)
• Fasting/Diabetes schematic (HERE)
• Utilizing acetoacetate (HERE)
• Diabetic ketosis (HERE)

Fatty Acid Synthesis

• Acetyl-CoA to Malonyl-CoA (HERE)
• Acyl carrier protein (HERE)
• Synthesis reactions HERE)
• Reaction Summary (HERE)
• Fatty acid synthase schematic (HERE)
• Transfer of acetyl-CoA to the cytosol (HERE)
• Pathway integration (HERE)
• Control of acetyl-CoA carboxylase (HERE) and HERE (Filaments - HERE)
• Desaturation of fatty acids in endoplasmic reticulum
• Unsaturated fatty acids
  • Linolenate (omega 3)
  • Linoleate (omega 6)
  • Palmitoleate (omega 7)
  • Oleate (omega 9)

Arachidonate and Prostaglandin Synthesis (Eicosanoids)

Reaction summary (HERE)

Eicosanoid structures (HERE)

General Info on Prostaglandins HERE