Citric Acid Cycle Outline
Notes HERE

Overview HERE and HERE

• Cellular respiration overview HERE
• Mitochondrion structure HERE / Schematic HERE
• Pyruvate entry HERE / Acetyl-CoA HERE

Pyruvate Dehydrogenase Complex

• Image HERE
• Components HERE
• Thiamine pyrophosphate (TPP) and Lipoic Acid HERE
• Overview of mechanism HERE
• Decarboxylation mechanism HERE and HERE
• Transfer of acetyl group to lipoamide (oxidation) HERE
• Transfer of acetyl group to CoA HERE
• Transfer of electrons to FAD and then to NAD+, creating NADH HERE
• Lipoamide HERE
• Enzyme core structure HERE and HERE
• Reaction schematic HERE

Citric Acid Cycle

Reactions

• Formation of citrate HERE
• Citrate <=> Isocitrate HERE / binding to aconitase HERE
• Isocitrate + NAD⁺ <=> Alpha-ketoglutarate + NADH+H⁺ HERE
• Alpha-ketoglutarate + CoA + NAD⁺ <=> Succinyl-CoA + CO₂ + NADH+H⁺ HERE
• Succinyl-CoA + Pi + (ADP) GDP <=> Succinate + CoA + (ATP) GTP HERE
• Succinate + FAD <=> Fumarate + FADH₂ + H₂O <=> L-Malate + NAD⁺ <=> Oxaloacetate + NADH+H⁺ HERE
• Cycle reactions HERE / Summary HERE

Cycle Regulation

• Relation to glycolysis HERE
• Pyruvate dehydrogenase complex regulation HERE and HERE
• Cycle regulatory points HERE

Anaplerotic Nature of Cycle HERE

Pathway integration HERE

Pyruvate Metabolism and Arsenic Poisoning HERE

Glyoxylate cycle HERE