Cellular Signaling Outline

(Move to Notes HERE)

Overview (HERE and HERE)

• Second Messengers (HERE)

7TM Receptors - Functions HERE / Depiction HERE and HERE / Ligand HERE

• Beta-adrenergic receptor pathway (HERE)
• G proteins HERE - schematic of alpha, beta, gamma subunits (HERE)
• Adenylate Cyclase (HERE)
• Epinephrine signaling HERE
• Resetting G-Proteins (HERE) and Signal Termination (HERE
• Phospholipase C reaction (HERE) at Membrane Surface (HERE)

Calcium as a Cytosolic Messenger

• EF Hands HERE
• Calmodulin binding HERE

Receptor Dimerization

• Insulin structure HERE
• Insulin receptor HERE / Catalytic activity HERE / Receptor activation by phosphorylation HERE
• Insulin signaling HERE
• SH2 Domain HERE
• Lipid kinase in signaling HERE
• Insulin signaling pathway overview HERE
• Epidermal Growth Factor HERE
• Epidermal Growth Factor Receptor structure HERE / dimerization HERE and HERE
• EGF signaling overview HERE
• Ras family GTPases HERE

Signaling Defects and Health

• SRC structure (HERE)
• bcr-abl gene translocation HERE