Metabolism and Metabolic Control Outline

(Move to Notes here)

Interconnected Pathways - Glucose Metabolism (HERE) / Metabolic Roadmap (HERE)

Thermodynamics and Reaction Direction - Delta G, Keq

ATP as Energy Currency (HERE)

To understand chemical reactions in cells, we must understand the thermodynamics (energy) of the reactions. The free energy of a process is the energy available to do useful work. The free energy of a process is called the Gibbs Free Energy. Most commonly, we are concerned with the change in free energy for a system. For example, for an enzymatically catalyzed reaction, we are interested in the change in free energy between the reactants and the products. The change in free energy (G) indicates the favorability of a process.

a. If the G for a process is negative, the forward process is favored.

b. If the G for a process is positive, the forward process is not favored and the reverse of the process is favored).

c. If the G for a process is zero, the process is at equilibrium.

Example:

For A <=> B,

if G is negative, A->B is favored.

if G is positive, B-> A is favored.

if G is 0, B-> A and A-> B are equally favored. The system is at equilibrium.

G = G0' + RTln[Products/Reactants] or, for the above reaction,

G = G0' + RTln[B/A]

Structure and Phosphate Energy

Exercise and Energy HERE - Reaction = Creatine + ATP <=> Creatine Phosphate + ADP / G0' = +12 kJ/mol

Energy Generation/Expenditure HERE

Oxidation Energy HERE

Cellular Energy Sources HERE

Metabolic Catabolism HERE

Oxidation / Reduction

Metabolic Carrier Molecules

Metabolic Reaction Types HERE

ADP as a Building Block HERE