Glycolysis & Gluconeogenesis Outline

(Move to Glycolysis Notes here)

Introduction (HERE)

Glycolysis Breakdown (Overview HERE)

• Stage I - Energy Investment - HERE
  • Reaction 1 - HERE - Induced Fit of Hexokinase HERE
  • Reaction 2 - HERE
  • Reaction 3 - HERE
  • Reaction 4 - HERE
  • Reaction 5 - HERE - Triose phosphate isomerase HERE, Mechanism HERE, Consideration HERE

• Stage II - Energy Generation - HERE
  • Reaction 6 - HERE and HERE, G3PDH HERE
  • Reaction 7 - HERE
  • Reactions 8,9,10 - HERE
    
    
• Overall Summary HERE
  
  
• Redox Balancing HERE and HERE
  • Pyruvate Fates HERE / Ethanol Formation HERE / Lactate Formation HERE
  • Pathogenic obligate anaerobes HERE
  • Fermentation options HERE
    
    
• Entry of Other Sugars HERE
  • Fructose Metabolism HERE
  • Galactose Metabolism HERE and HERE / Cataract Consideration HERE
  • Lactose Metabolism/Intolerance HERE
    
    
• Regulation
  • Phosphofructokinase HERE and HERE.
    • Activation by F2,6BP HERE
    • Structure of F2,6BP HERE
  • Regulation in muscle HERE and HERE
  • Pyruvate kinase regulation HERE
    
    
• Other Considerations
  • Glucose Transport Proteins HERE
  • Glycolysis and Hypoxia/Cancer HERE and HERE

Glucose Synthesis

• From glycerol HERE
• Gluconeogenesis (Overview HERE)
  • Pyruvate Carboxylase HERE
    • Biotin binding HERE
    • Carboxybiotin HERE
  • PEP Carboxykinase (PEPCK) HERE
  • Glucose-6-phosphatase HERE

Glycolysis / Gluconeogenesis Regulation

• Reciprocal Regulation of Glycolysis and Gluconeogenesis HERE
• Phosphofructokinase 2 HERE
• Fructose 2,6 Bisphosphate Synthesis & Degradation HERE

Cori Cycle

• Schematic HERE and HERE