Neil Shay

Dr. Neil Shay, Professor
Food Science and Technology

B.S. - 1976 University of Massachusetts, Zoology
M.A. - 1979 University of Massachusetts, Physics/Education
Ph.D. - 1990 University of Florida, Biochemistry and Molecular Biology

Professional Activities
Editorial Board Member: Journal of Nutrition
Member: American Society of Nutrition, Institute of Food Technologists, American Society for Enology and Viticulture

Research Interests: 

Functional Foods and Their Bioactive Components: Components of fruits and vegetables that influence human metabolism, with a special focus on compounds of fruits and vegetables and their influence on heart disease and diabetes. Wine and Health


Representative Publications
Gourineni V, Shay NF, Chung S, Sandhu AK, Gu L.  (2012) Muscadine grape (Vitis rotundifolia) and wine phytochemicals prevented obesity-associated metabolic complications in C57BL/6J mice.  J Agric Food Chem. 2012 Aug 8;60(31):7674-81.

Cho K.W., Lee O.H., Banz W.J., Moustaid-Moussa N., Shay N.F., Kim Y.C. (2010) Daidzein and the daidzein metabolite, equol, enhance adipocyte differentiation and PPARgamma transcriptional activity.  J Nutr Biochem. Sep;21(9):841-7.

Li Y., Ross-Viola J.S., Shay N.F., Moore D.D., Ricketts M.L. (2009) Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner.  J Nutr. 2009 May;139(5):898-904.

Davis J., Higginbotham A., O'Connor T., Moustaid-Moussa N., Tebbe A., Kim Y.C., Cho K.W., Shay N., Adler S., Peterson R., Banz W.  (2007) Soy protein and isoflavones influence adiposity and development of metabolic syndrome in the obese male ZDF rat.  Ann Nutr Metab. 2007;51(1):42-52.

Li Y, Mezei O, Shay NF.(2007) Human and murine hepatic sterol-12-alpha-hydroxylase and other xenobiotic metabolism mRNA are upregulated by soy isoflavones.J Nutr. 2007 Jul;137(7):1705-12.

Mezei, O., Ross-Viola, J., Mullen, E., Li, Y., and Shay, N.F.  (2006) Genetically-altered PPAR-alpha knockout mice indicate hypolipidemic actions of soy isoflavones occur via PPAR-alpha dependent and independent mechanisms.  Physiological Genomics, 2006 26(1):8-14.

Mullen, E., Brown, R.M., Osborne, T.F., and Shay, N.F. (2004) Soy Isoflavones Affect Sterol Regulatory Element Binding Proteins (SREBPs) and SREBP regulated genes in HepG2 cells. J Nutrition. 134: 2942-2947.

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