Extreme Hazard Carcinogens

SECTION 3 - EXTREME HAZARD CARCINOGENS

Authorization for Use

Designation of Person in Charge.

Content of Protocols.

The individual in charge of a project involving the use of Extreme carcinogens shall prepare a written protocol in consultation with EH&S to include, but not be limited to, the following information:

  1. Name of principal investigator and/or project supervisor. First time applicants attach C.V.
  2. Names of all other laboratory personnel associated with the project.
  3. Names, amounts, and concentrations of chemical carcinogens involved.
  4. Description of experimental procedures, including:
    • Overall nature of the study.
    • Concentrations and amounts of stock and working solutions, and methods for routine decontamination and disposal.
    • Techniques and equipment to assure containment.
    • Emergency procedures including deactivation and/or decontamination.
    • Personal protective measures to be employed and/or equipment to be used.
    • Description of physical facilities where proposed study will be done.

Review and Approval of Protocols.

  1. Departmental Review:
    • In addition to the protocol, the principal investigator must complete an Application/Registration for Use of Chemical Carcinogens (Appendix 1).
    • If animals are to be used in the experiment, a Chemical Agent Use in Animals form must be completed.
    • The completed forms and protocol must be reviewed and approved by the department chairperson.
    • The completed forms and the approved protocol will be forwarded through EH&S to the Chemical Safety Committee.
  2. Chemical Safety Committee Review:
    • After departmental approval, the completed forms and the accompanying protocols will be reviewed by the Chemical Safety Committee in consultation with EH&S, the consulting physician, and if animals are to be used, by the campus veterinarian.
    • Final approval by the Chemical Safety Committee must precede initiation of proposed projects or laboratory teaching exercises.
  3. EH&S Review:
    • Following approval by the Chemical Safety Committee, the submitted forms and accompanying protocols will be placed on file in the EH&S office.

Notification To Add or Delete Personnel.

Amendments To Approved Protocols.

Duration of Authorization.

  1. Initial Period of Authorization: Authorization for the use of Extreme carcinogens by the Chemical Safety Committee are approved for three years. Substantive changes in use or procedures will require re-authorization
  2. Period of Review of Authorization: All authorizations will be updated by the investigator and reviewed by the Chemical Safety Committee at 3-year intervals to assure that protocols, procedures and usage comply with the initial authorization.

Physical Facilities

Isolated Systems

  1. Physical facilities for use of Extreme carcinogens shall be capable of providing either an isolated system or a totally controlled access facility with an independent ventilation system. For most uses, the most practical alternative is a glove box with an appropriately treated exhaust system approved by EH&S.
  2. Laboratory must be under negative pressure with respect to general access areas such as hallways and offices.
  3. The following criteria are required of all laboratories in which Extreme carcinogens are used or stored:
    • Isolated systems must be provided with an approved exhaust treatment system.
    • Isolated systems and approved storage cabinets must be labeled "Caution - Select Carcinogen."

Working Outside Isolated Systems.

If the procedures involved in the use of Extreme carcinogens cannot be contained in an approved isolated system, the following features must be provided in the laboratory:

  1. Laboratory must be under negative pressure with respect to general access areas such as hallways and offices.
  2. Entrances must be posted with "Cancer Suspect Agent."
  3. Vacuum lines must be appropriately protected to prevent entry of the carcinogens used into the lines.
  4. Prior to commencing work with chemical carcinogens, the laboratory ventilation system must be approved by EH&S.
  5. Laboratory work surfaces shall be protected from contamination by the use of disposable, absorbent paper with moisture-proof backing.
  6. Authorized entry into the laboratory must be regulated by a system approved by the Chemical Safety Committee.
  7. The laboratory shall be equipped with an approved air exhaust system that is independently ducted, under negative pressure in interior spaces, and does not recirculate air.
  8. General room exhausts, glove boxes, laboratory hoods, or biological safety cabinets shall be equipped with approved exhaust treatment systems. (The appropriate exhaust for any carcinogen is dependent upon the nature of the compound and will be determined in the protocol phase of the experiment. Recommended equipment for treatment includes, but is not limited to, HEPA filters, activated charcoal filters, exhaust incinerators, and/or chemical scrubbers.)
  9. Provision shall be made for shower facilities and the management of protective clothing in the regulated area.
  10. The regulated area must contain a roster of persons who enter the facility.

Animal Care Facilities.

Storage and Labeling

Labeling of Containers.

Storage.

Inventory.

  1. A complete, current inventory of each Extreme chemical carcinogen shall be maintained in the secured storage area. The inventory record shall include:
    • The quantity of chemical carcinogen originally acquired.
    • The name of the authorized individual removing the material, the date, and amount removed.
    • The date and final disposition of the remaining material.
  2. Inventory records shall be kept up to date in the university's on-line inventory program.

Transportation of Extreme Hazard Carcinogens

Transport On Campus.

Transport Off Campus.

Transport Within Laboratories

Vacuum Line Protection

  1. HEPA filters or other approved devices must be used to prevent entry of carcinogenic chemicals into the vacuum system is required.
  2. Vacuum line protective systems shall be approved by EH&S prior to use.
  3. When using a volatile carcinogen, a separate vacuum pump or other device vented to an approved laboratory hood shall be used.

Housekeeping

Personal Protection

Extreme carcinogens NOT used in an Isolated System

Extreme carcinogens used in Animal Care Facilities.

Protective Clothing

All standard laboratory safety practices, such as the wearing of eye protection, shall be observed in addition to the following:

  1. When working with Extreme chemicals, employees must wear a laboratory coat, protective gloves, and shoes which cover the entire foot.
  2. When working inside regulated Extreme carcinogen areas, employees shall be required to wear clean, protective laboratory clothing such as a surgical gown, surgical scrub suit, or fully buttoned laboratory coat and head cover, protective shoe covers, and gloves.
  3. Prior to each exit from the regulated area, employees shall be required to remove and leave protective clothing at the point of exit.
  4. At regular intervals or when overtly contaminated, used protective clothing shall be placed in impervious containers for the purpose of decontamination or disposal. The impervious container shall be labeled "Cancer Suspect Agent."
  5. Required protective clothing for employees working with animals not contained in a glove box and using Extreme carcinogens shall include coveralls, protective shoe covers, head covers, gloves, and respirators approved by EH&S.
  6. Personnel involved in maintenance or decontamination of facilities in which Extreme carcinogens are used shall be required to wear clean protective garments, including gloves, protective shoe covers, head covers, and when required, respirators.

Certification Of Laboratory Hoods And Isolated Systems.

Medical Surveillance

Preassignment Examinations.

Periodic Examinations.

Content.

Records.

Physician requirements

Inspections Required

All projects using Extreme carcinogens are subject to periodic inspections (announced or unannounced) by EH&S or the Chemical Safety Committee in order to insure safe conditions and procedures. EH&S or the Chemical Safety Committee may also inspect any project where potentially carcinogenic chemicals are being used.Inspections of projects using Extreme carcinogens will include, in part:

  1. A review of the physical facilities to see if enclosures and other safety equipment are functioning correctly.
  2. Determination that materials required to cope with accidents are readily available and emergency procedures are displayed.
  3. Determination that all personnel involved in the project are familiar with appropriate normal and emergency procedures and are aware of the potential hazards of the work of their own group as well as those of any other group with whom the facilities are shared.
  4. Determination that appropriate procedures for biological, physical, and chemical containment are consistent with approved protocols.
  5. Review of the roster maintained at regulated areas where the Extreme carcinogens are used. (See Laboratory Use of Extreme carcinogens Outside Isolated Systems, this section).
  6. Review of the inventory of Extreme carcinogens.

The results of inspections will be brought to the immediate attention of the principal investigator, the department chairperson, and reported to the chairperson of the Chemical Safety Committee. Inspection reports will be retained as part of the permanent files of EH&S.

Posting of Emergency Procedures

Approved specific emergency procedures shall be prescribed and posted in areas using Extreme carcinogens. The posted information shall include, but not be limited to:

  1. Name and phone number of principal investigator, department chairperson, EH&S, and Campus Police and Security.
  2. Decontamination procedure.
  3. Location of closest shower facility.