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VIII. Special Precautions
B. Allergens, Embryotoxins and Teratogens C. Chemicals of High Acute Toxicity
B. Allergens, Embryotoxins and Teratogens
C. Chemicals of High Acute Toxicity
- Areas where these chemicals are stored and used will have restricted access and have [specific] warning signs naming the hazard types.
- Vacuum pumps when used with these chemicals must have scrubbers or High Efficiency Particulate Absolute (HEPA) filters.
- Approval of the Lab Supervisor/PI will be obtained before initiating a new procedure using these chemicals.
D. Chemicals of High Chronic Toxicity
- Such chemicals will be maintained in labeled, unbreakable, chemically resistant containers and stored in a limited-access area appropriate for the chemical.
- Areas where such agents are used shall be identified by a sign on the hood, glove box or lab area.
- The Lab Supervisor/PI will be knowledgeable of chemicals in use and will approve new procedures prior to implementation.
- Vacuum pumps when used with these chemicals must have scrubbers or High Efficiency Particulate Air (HEPA) filters.
- Any contaminated equipment or glassware will be decontaminated as soon as possible and before further use.
- For powders, a wet mop or vacuum with a HEPA filter will be used for cleanup, and the waste will be immediately disposed of.
E. Animal Research
- All chemicals used in the animal caging/holding areas must be noted in the animal use protocol approved, prior to use of chemicals, by the Institutional Animal Care and Use Committee (IACUC).
- The PI is required to work with IACUC and the OSU Chemical Hygiene Officer to:
- Develop procedures for the appropriate handling of animals, their wastes, cages, and disposal of the animal to prevent personnel exposure to the contaminant. Assure that personal protective equipment (per protocol) is worn by all persons handling these materials.
- Prepare animal hazard warning signs which are to be posted in the animal housing area.
- Notify employees in the area of use before each use of the chemical agent in animals (i.e., when first initiating use and when beginning again after a layoff, to assure staff are aware of the impending usage).
- Administer chemical substances by injection or lavage when possible, rather than by diet. When administration by diet is used, a caging system under negative pressure or under laminar air flow directed through High Efficiency Particulate Air (HEPA) filters will be used.
- Use procedures to minimize contaminated aerosols from food, urine and feces, including:
- Use HEPA filtered vacuum equipment for cleaning;
- Moisten contaminated bedding before removal from cage.
- Wear appropriate resistant gloves and fully buttoned lab coats or coveralls in the animal room and when working with exposed animals.
- For large scale studies with animals administered chemicals of high chronic toxicity, special facilities with restricted access must be used.
F. Radioactive materials
- The EH&S radiation safety group is responsible for all radioactive substances and places additional restrictions on chemical substances or agents referred to in this Plan that are also radioactive.
G. Recombinant DNA
- The OSU Biosafety Committee may place additional restrictions on certain experiments involving recombinant DNA.
- The University BioSafety Officer should be contacted regarding notification and approval procedures.
H. Infectious Agents