B.S. - 1965 Eastern Illinois University, Zoology/Chemistry
Ph.D. - 1973 University of Illinois, Food Science
Member of the toxicology graduate program, Oregon State University. American Society of Neurochemistry; Institute of Food Technologists; Society of Toxicology; International Society for Xenobiotics; American Oil Chemist's Society; Sigma Xi.
My research is concerned with the toxicology of 2, 3, 7, 8 tetrachlorodibenzo-p-dioxin (TCDD), a compound of great environmental concern. This compound is the most toxic congener of the polychlorinated dioxin class of compounds. It elicits a wide range of toxic effects, including alterations in metabolic pathways. Many of the toxic effects are mediated through a cellular protein known as the aryl hydrocarbon (Ah) receptor. The purpose of our research is to study the involvement of the Ah-receptor in pyruvate carboxylase gene regulation. Pyruvate carboxylase is an enzyme
involved in intermediary metabolism leading to the eventual synthesis of ATP. TCDD down regulates the enzyme pyruvate carboxylase which is key to the synthesis of oxaloacetate. We have recently shown that pyruvate carboxylase mRNA and protein levels decrease in C57BL/6J mice injected with TCDD. This decrease appeared dose dependent and was observed between 16 and 192 hours post injection to TCDD. The mechanism(s) responsible for this down regulation of pyruvate carboxylase is under investigation. An understanding of the mechanism may help
to understand TCDD wasting that is commonly associated with exposure to this compound. We are also involved in studiees to produce aniline adulterated toxic oils from low erucic acid rapeseed oil (canola oil). This study is a result of a collaboration with the Center for Disease Control and the Government of Spain. The purpose of the study is to produce the actual compounds that caused the death and illness of several thousand people in Madrid, Spain during 1982. A number of triacylglycerol derivatives of aniline have been isolated and purified. These compounds will be
used in animal studies to establish their toxicity.
Carpenter, H.M., Zhang, Q., El Zahr, C., Selivonchick, D.P., Brock, D.E., and Curtis, L.R. 1995. In vitro and in vivo temperature modulation of hepatic metabolism and DNA adduction of aflatoxin B1 in rainbow trout. J. Biochem. Toxicol. 10:1-10 .
Curtis, L.R., Zhang, Q. , El-Zahr C. , Carpenter, H.M., Miranda, C.L., Buhler, D.R., Selivonchick, D.P. , and Hendricks, J.D. 1995. Temperature-modulated incidence of aflatoxin B1-initiated liver cancer in rainbow trout. Fund. Appl. Toxicol. 25:146-153.
Rodrigues, L.E., Barrett, D.M., and Selivonchick, D.P. 1995. Influence of peroxidase and lipoxygenase on the stability of polyunsaturated fatty acids in sweet corn (Zia Mays L.) during frozen storage. J. Food Science 60:10-41-44.
Sparrow, B.R., Thompson, C.S., Ryu, B.W., Selivonchick, D.P., and Schamp, H.W. 1994. 2, 3, 7, 8 - Tetrachlorodibenzo-p-dioxin induced alterations of pynivate carboxylase levels and lactate dehydrogenase isozyme shifts in C57B1/6J male mice. J. Biochem. Toxicol. 9:329-335.
Zhang, Q., El-Zahr, C., Carpenter, H.M., Selivonchick, D.P., and Curtis, L.R. 1992. Temperature acclimation differentially modulates metabolic pathways for aflatoxin B1 in rainbow trout. Toxicologist 12:326.
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