Investigating the Role of Fas among Activated T-Cells
Presented by: Tyler Creelen
Mentor: Anthony Vella
Department of Microbiology, Oregon State University
A member of the tumor necrosis factor (TNF) family of cell receptors, Fas, also known as CD95, is expressed in T-cells and is known to signal programmed cell death, or apoptosis. This death signal may be induced by binding Fas to the Fas ligand, thus sending the affected cell into death cycle. This process may be mimicked in the laboratory by binding an agonist antibody (anti-Fas) to Fas. We are investigating the relationship between activation and Fas-induced apoptosis. Recent findings indicate that binding Fas may cause cell proliferation rather
than apoptosis among super-activated T-cells.