Mismatch Repair (MMR) Responses to DNA Lesions

Conference Schedule

Friday, September 9 Oregon Health & Science University

11:00 am - 3:30 pm Conference Shuttle - Portland International Airport to OSHU

11:30 am - 4:30 pm Registration check-in

4:00 pm - 5:00 pm Welcome Reception

5:00 pm - 8:15 pm Session I - Biochemical Mechanisms

5:00 pm - 5:35 pm Peggy Hsieh - Session Chair
National Institutes of Health
MMR mutation avoidance functions in yeast and mammals.

5:35 pm - 6:10 pm John Hays
Oregon State University
Activities of MMR recognition complexes at base-mismatches and mismatched UV photoproducts.

6:10 pm - 6:40 pm Supper Break

6:40 pm - 7:05 pm Jim Drummond
Indiana University
Human MMR responses to oxidized purines, O6-methylguanine and other lesions in vitro.

7:05 pm - 7:50 pm Poster Presentations

7:50 pm - 8:15 pm Discussion

8:30 pm Load Bus for Shuttle to Oregon State University

10:45 pm Arrive OSU - Cauthorn Hall for Lodging

Saturday, September 10 Oregon State University

8:00 am - 8:45 am Continental Breakfast - Giustina Gallery, LaSells Stewart Center

9:00 am - 12:30 pm Session II - Cellular Surveillance and Signaling.

9:00am - 9:35 am Niels de Wind - Session Chair
Leiden University Medical Center, Leiden, The Netherlands
MMR involvement in UV-induced s-phase arrest and mutagenesis.

9:35 am - 10:05 am Margherita Bignami
Instituto Superiore di Sanita, Rome, Italy
MMR and oxidative damage

10:05 am - 10:35 am Alan Clarke
University of Cardiff, UK
MMR-dependent apoptosis in the mouse small intestine in response to alkylating agents.

10:35 am - 11:00 am Break

11:00 am - 11:30 am Rajaskeran Baskaran
University of Pittsburgh
MMR-dependent cell-cycle-checkpoint activation in response to cisplatin and alkylating agents

11:30 am - 12:00 pm David Boothman
University of Texas SW Medical Center
MMR-mediated G2 arrest responses and apoptosis following MNNG exposure

12:00 pm - 12:30 pm Discussion

12:30 pm Lunch/Open Afternoon

12:45 pm -3:30 pm Winery Tour - Cristom Winery, Bethel Heights Vineyard, Witness Tree Vineyard

4:30 pm - 5:00pm Light Refreshments - LaSells Stewart Center

5:00 pm - 7:30 pm Session III - Implications for Mutagenesis and Carcinogenesis.

5:00 pm - 5:25 pm Peter Karran - Session Chair
Cancer Research Fund, UK
Drug resistance, MMR defects, and therapy-related acute myeloid leukemia in organ-transplant patients.

5:25 pm - 5:50 pm Andrew Buermeyer,
Oregon State University
MMR suppression of hetercyclic-amine-induced mutagenesis and carcinogenesis.

5:50 pm - 6:15 pm Mitchell Turker
Oregon Health & Science University
Unexpected MMR roles in suppression of mutation induced by UV irradiation, oxidative DNA damage, and IR.

6:15 pm - 6:40pm Winfried Edelmann
Albert Einstein Medical Center
Cancer predisposition and responses to DNA damage in MMR-deficient mice.

6:40 pm - 7:05 pm Rick Boland
Baylor University Medical Center
Implications of defective MMR for colorectal
cancer.

7:30 pm - 8:30 pm Dinner Buffet - Courtyard, LaSells Stewart Center

8:30 pm - 11:00 pm Poster Session

Sunday, September 11 Oregon State University

6:45 am - 9:00 am Continental Breakfast - Cauthorn Hall Lounge

TBA Airport Shuttle departing to PDX